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首页- Products - Others - Other Targets - IFN alpha-IFNAR-IN-1 hydrochloride

IFN alpha-IFNAR-IN-1 hydrochloride

CAS No. 2070014-98-9

IFN alpha-IFNAR-IN-1 hydrochloride ( —— )

产品货号. M26256 CAS No. 2070014-98-9

IFN α-IFNAR-IN-1 saltchide 是 IFN-α 和 IFNAR 之间相互作用的抑制剂。 IFN α-IFNAR-IN-1 saltchide 抑制 BM-pDCs 诱导的 MVA IFN-α 反应,IC50 为 2-8 μM。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥478 有现货
5MG ¥778 有现货
10MG ¥1045 有现货
25MG ¥1806 有现货
50MG ¥2827 有现货
100MG ¥4228 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    IFN alpha-IFNAR-IN-1 hydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    IFN α-IFNAR-IN-1 saltchide 是 IFN-α 和 IFNAR 之间相互作用的抑制剂。 IFN α-IFNAR-IN-1 saltchide 抑制 BM-pDCs 诱导的 MVA IFN-α 反应,IC50 为 2-8 μM。
  • 产品描述
    IFN alpha-IFNAR-IN-1 hydrochloride is an inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits MVA-induced IFN-α responses by BM-pDCs with IC50 of 2-8 μM.(In Vitro):IFN alpha-IFNAR-IN-1 hydrochloride inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 hydrochloride specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 hydrochloride exerts immunosuppressive activity by the direct interaction with IFN-α.
  • 体外实验
    IFN alpha-IFNAR-IN-1 (compound 1) (18 μM; 24 h) specifically inhibits MVA-induced IFN-a responses by BMpDCs.
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    antimalarial
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    2070014-98-9
  • 分子量
    315.86
  • 分子式
    C18H18ClNS
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 100 mg/mL (316.60 mM)
  • SMILES
    Cl.CNCc1ccccc1Sc1cccc2ccccc12
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Marcsisin SR, et al. Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds. Malar J. 2014 Jan 3;13:2.
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